High-Resolution Metabolomics
نویسندگان
چکیده
منابع مشابه
Detailed Mitochondrial Phenotyping by High Resolution Metabolomics
Mitochondrial phenotype is complex and difficult to define at the level of individual cell types. Newer metabolic profiling methods provide information on dozens of metabolic pathways from a relatively small sample. This pilot study used "top-down" metabolic profiling to determine the spectrum of metabolites present in liver mitochondria. High resolution mass spectral analyses and multivariate ...
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Interstitial fluid (ISF) surrounds the cells and tissues of the body. Since ISF has molecular components similar to plasma, as well as compounds produced locally in tissues, it may be a valuable source of biomarkers for diagnostics and monitoring. However, there has not been a comprehensive study to determine the metabolite composition of ISF and to compare it to plasma. In this study, the meta...
متن کاملHigh-resolution metabolomics of occupational exposure to trichloroethylene
BACKGROUND Occupational exposure to trichloroethylene (TCE) has been linked to adverse health outcomes including non-Hodgkin's lymphoma and kidney and liver cancer; however, TCE's mode of action for development of these diseases in humans is not well understood. METHODS Non-targeted metabolomics analysis of plasma obtained from 80 TCE-exposed workers [full shift exposure range of 0.4 to 230 p...
متن کاملDeployment-Associated Exposure Surveillance With High-Resolution Metabolomics.
OBJECTIVE The aim of this study was to assess the suitability of high-resolution metabolomics (HRM) for measure of internal exposure and effect biomarkers from deployment-related environmental hazards. METHODS HRM provides extensive coverage of metabolism and data relevant to a broad spectrum of environmental exposures. This review briefly describes the analytic platform, workflow, and recent...
متن کاملAnalyzing and Mapping Sweat Metabolomics by High-Resolution NMR Spectroscopy
The content of human sweat is studied by high-resolution NMR, and the majority of organic components most often found in sweat of conditionally healthy people are identified. Original and simple tools are designed for sweat sampling from different areas of human body. The minimal surface area needed for sampling is in the range of 50-100 cm(2). On all the surface parts of the human body examine...
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ژورنال
عنوان ژورنال: Biological Research For Nursing
سال: 2015
ISSN: 1099-8004,1552-4175
DOI: 10.1177/1099800415595463